Understanding My Prolaris Results

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A Prolaris Score is important because it shows how aggressively your individual cancer is acting and gives you and your doctor a clearer insight into treatments that will be right for you, because every man deserves better answers.

Here are the basics of what your report means. Click the number of the section you wish to learn more about.

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ProlarisScore Box

  • Your Prolaris Score is calculated by measuring genes in your tumor, which describe the behavior and aggressiveness of the tumor.
  • Most Prolaris Scores fall between 0-10, with a higher score meaning that the cancer is more aggressive.
  • A Prolaris Score is important because it shows how aggressively your individual cancer is acting and gives a clearer insight into treatments that will be right for you.
  • DSM Risk: Explained in below section.
  • Risk Category: NCCN risk group explained further in “Variables Used for Risk Assessment” Section.

Variables Used forRisk Assessment

  • Clinical variables like age, PSA, Gleason Score, etc. are combined with your Prolaris Molecular Score to calculate the 10-year risk assessment (below).
  • PSA –What is PSA? Click here to learn more.
  • Clinical T Stage: The T staging of a prostate cancer tumor is used to describe the size and location of the tumor. To see a full breakdown of the different stages, click here.
  • % Positive Cores: The percentage of cancer positive cores are found using the samples from the biopsy. During biopsy, most urologists will take 6-12 tissue samples from different areas of the prostate using a needle. Then each sample is examined to determine how many were positive for cancer.
  • Gleason Score: If prostate cancer is found in the biopsy it will be assigned a Gleason score to identify how far your cancer has advanced. The primary, most frequent pattern of the cancer is given a grade from 1-5 with 5 being the most different from the healthy prostate tissue. The second most common pattern of the cancer is also given a grade between 1-5. Those two grades are added together to make a Gleason score.
  • Cancer with a Gleason score of 8-10 represent high grade cancers that tend to be more aggressive forms of cancer.
  • NCCN Risk: The National Comprehensive Cancer Network (NCCN) provide recommended guidelines based on what risk group your cancer falls under. To view the quick guide of your risk, click here.

Patient’sRisk Assessment

When Considering Active Surveillance:
  • Your Disease Specific Mortality (DSM) is the risk of dying from prostate cancer in 10 years if you choose active surveillance over definitive treatment.
    • To learn more about active surveillance, click here.
  • The DSM is calculated using your Prolaris Score and your Clinical Pathological features from the two boxes above.
  • If your DSM falls within the grey box (the active surveillance threshold) then you are considered an appropriate candidate for active surveillance.
  • If your DSM falls outside of the threshold, definitive treatment should be considered.
When considering primary radiation therapy or radical prostatectomy:
  • If you are considering definitive treatment like radiation or radical prostatectomy, this is the risk of getting metastasis in the 10 years following the treatment.
    • Metastasis (METS): Means that your cancer has spread to a different part of your body. To learn more, click here.
    • To learn more about primary radiation therapy, radical prostatectomy, and other prostate cancer treatments, click here.
  • Note: The DSM risk and METS risk are independent from one another, choosing treatment or active surveillance won’t change your risk in the other category.

RiskStratification

  • This section of the report is illustrating your individual risk compared to the standard risk of other patients in the same NCCN risk group (see Variables Used for Risk Assessment section to learn more about the NCCN risk group).
  • The shaded grey area represents the active surveillance threshold that was shown on the bottom left of the first page of the report (When Considering Active Surveillance section).
  • The triangles represent the standard risk for patients within the specified risk group.
  • The person icon represents your risk and where you fall compared to the standard risk of other patients. It also shows whether you fall within the threshold and are considered appropriate for active surveillance.

ResultsInterpretation

  • The clinical interpretation of your report and the above graph.