Understanding the Prolaris Report

Prolaris® explains the behavior of the tumor to provide the risk of Disease Specific Mortality (DSM) and metastasis.

Click the number of each section to learn more.

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ProlarisScore Box

  • The Prolaris Molecular Score is calculated by measuring the expression of 31 cell cycle progression (CCP) genes in the tumor. This describes the behavior of the tumor.
  • The majority of Prolaris Molecular Scores fall between 0-10, with a higher score indicating more aggressive cancer.1, 2

Variables Used forRisk Assessment

  • Clinical variables and the Prolaris Molecular Score are used to calculate a patient’s risk assessment.

Patient’sRisk Assessment

When Considering Active Surveillance:
  • When considering active surveillance, patients with a DSM within the grey box may be considered appropriate for active surveillance.3
When considering primary radiation therapy or radical prostatectomy:
  • When considering definitive treatment, the patient’s 10-year risk of developing metastasis is provided.

RiskStratification

  • Patient’s risk of DSM compared to other patients in the same NCCN risk group.
  • The grey shaded box represents the active surveillance threshold.

Sources:

  1. Cuzick J, Berney DM, Fisher G, et al; Transatlantic Prostate Group. Prognostic value of a cell cycle progression signature for prostate cancer death in a conservatively managed needle biopsy cohort. Br J Cancer. 2012;106(6):1095-1099.
  2. Data on file. Salt Lake City, UT: Myriad Genetic Laboratories, Inc.
  3. Lin DW, et al. Identification of men with low-risk biopsy-confirmed prostate cancer as candidates for active surveillance. Urologic Oncology: Seminars and original investigations. 2018.